| Flight | Launch Date | Landing Date/Site | Mission details |
1. STS-1 | 4/12/1981 | 4/14/1981 | Maiden voyage; demonstrate safe launch and return. |
2. STS-2 | 11/12/1981 | 11/14/1981 | Demonstrate safe relaunch; mission cut short due to fuel cell failure.
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3. STS-3 | 3/22/1982 | 3/30/1982 | Another shakedown flight; all systems tested. |
4. STS-4 | 6/27/1982 | 7/4/1982 | Final test flight; carried a classified payload for the U.S. Department of Defense. |
5. STS-5 | 11/11/1982 | 11/16/1982 | First operational mission; deployed two communications satellites. |
6. STS-9 | 11/28/1983 | 12/8/1983 | Flight carried first Spacelab mission. |
7. 61-C | 1/12/1986 | 1/18/1986 | Last pre-Challenger flight, satellite deployed. |
8. STS-28 | 8/8/1989 | 8/13/1989 | Mission for Department of Defense. |
9. STS-32 | 1/9/1990 | 1/20/1990 | Deployed defense satelitte, retrieved previously launched space equipment. |
| 10. STS-35 | 12/2/1990 | 12/10/1990 | Gathered astronomical data. |
| 11. STS-40 | 6/5/1991 | 6/14/1991 | Dedicated Spacelab mission with focus on the life sciences. |
| 12. STS-50 | 6/25/1992 | 7/9/1992 | Carried Spacelab module for microgravity research. |
| 13. STS-52 | 10/22/1992 | 11/1/1992 | Deployed Laser Geodynamic Satellite. |
| 14. STS-55 | 4/26/1993 | 5/6/1993 | Deployed Spacelab module. |
| 15. STS-58 | 10/18/1993 | 11/1/1993 | Dedicated to life sciences research. |
| 16. STS-62 | 3/4/1994 | 3/18/1994 | Longer mission to study medical effects of space flight. |
| 17. STS-65 | 7/8/1994 | 7/23/1994 | More microgravity research. |
| 18. STS-73 | 10/20/1995 | 11/5/1995 | Conducted medical and engineering research. |
| 19. STS-75 | 2/22/1996 | 3/9/1996 | Minor instrument malfunction; tethered satellite experiment was cut short. |
| 20. STS-78 | 6/20/1996 | 7/7/1996 | More studies of effects of long-term space flight. |
| 21. STS-80 | 11/19/1996 | 12/7/1996 | 18-day flight retrieved previously deployed astrometrical research equipment. |
| 22. STS-83 | 4/4/1997 | 4/8/1997 | Mission cut short due to fuel cell problems. |
| 23. STS-94 | 7/1/1997 | 7/17/1997 | Completed microgravity research from aborted STS 83. |
| 24. STS-87 | 11/19/1997 | 12/5/1997 | Microgravity research |
| 25. STS-90 | 4/13/1998 | 5/3/1998 | Spacelab flight to study effects of microgravity on the nervous system. |
| 26. STS-93 | 7/23/1999 | 7/27/1999 | Deployed Advanced X-ray Microphysics Facility. |
| 27. STS-109 | 3/1/2002 | 3/12/2002 | Serviced Hubble Space Telescope. |
| 28. STS-107 | 1/16/2003 | 2/1/2003 | Crew and Vehicle lost during landing . |
Columbia was named after a small sailing vessel that operated out of Boston in 1792 and explored the mouth of the Columbia River. One of the first ships of the U.S. Navy to circumnavigate the globe was named Columbia. The command module for the Apollo 11 lunar mission was also named Columbia.